doi: 10.1097/WNR.0000000000001242, Zhang, X., Meng, X., Chen, Y., Leng, S. X., and Zhang, H. (2017). The temperature of the MWM room was kept at 24 2C. B. S., and Sharma, B. strings of text saved by a browser on the user's device. & Hou, X.G. 3). The paired-end reads that remained after quality control (low-quality reads containing >10% unknown bases or 50% low-quality bases) were mapped to our A. truncatum reference genome (Ma et al., 2020) using HISTA2 version 2.0.4 (Kim et al., 2015).

(2015). (2017). 27, 639650. WebComparing seed extract well prices. WebAqueous enzymatic extraction (AEE) of oil from Acer truncatum Bunge seed kernel was investigated. The DEGs related to lipid metabolism at different time points of A. truncatum seed development can provide important information about the key stages of oil accumulation and the mechanism regulating UFA synthesis.

21, 52465253.

Cold Spring Harb. In a seed oil analysis study of 138 accessions from 14 populations of Acer truncatum (Aceraceae) native to China, the level of C24:1x9 was reported to range from 3.9% to 7.85% [26]. & Sun, R.C. Latiffah First Report of Colletotrichum truncatum Causing Anthracnose of Dragon Fruit (Hylocereus spp.) Differentially expressed genes (DEGs) identified in Acer truncatum seeds at various development stages: (A) quantity of DEGs and (B) cluster analysis of DEGs. (2016). China Higher Educ. (2012). It is well known that aging is associated with chronic inflammation (Lopez-Otin et al., 2013; Minciullo et al., 2016). To validate the reliability of the RNA-seq results, 16 genes related to FA biosynthesis were selected for qRT-PCR validation (Fig. doi: 10.1016/j.cmet.2016.05.011, Bitto, A., Ito, T. K., Pineda, V. V., LeTexier, N. J., Huang, H. Z., Sutlief, E., et al. Recently, A. truncatum has emerged as an oil crop. Previous studies showed that LEC1, WRI1, FUS3, and ABI3 are key regulators of FA biosynthesis (Baud et al., 2007; Mu et al., 2008). Aging is a strong risk factor for multiple diseases including stroke, some aging-associated cancers, neurodegeneration, osteoarthritis, macular degeneration, and many other diseases.

Biol. Your current browser may not support copying via this button. ) 1995 Palmitoyl-acyl carrier protein (ACP) thioesterase and the evolutionary origin of plant acyl-ACP thioesterases Plant Cell 7 359 371 doi: 10.1105/tpc.7.3.359, Kanehisa, M., Araki, M., Goto, S., Hattori, M., Hirakawa, M., Itoh, M., Katayama, T., Kawashima, S., Okuda, S., Tokimatsu, T. & Yamanishi, Y. The first-strand cDNA was reverse-transcribed from 1 g total RNA with M-MLV reverse transcriptase (Promega, Madison, WI). 21 401 408 doi: 10.1046/j.1365-313x.2000.00686.x, Riechmann, J.L., Heard, J., Martin, G., Reuber, L., Jiang, C.Z., Keddie, J., Adam, L., Pineda, O., Ratcliffe, O.J. The four comparisons exhibited similar patterns of GO functional classification; however, they differed in enrichment classifications (Supplemental Fig. Acer truncatum A. truncatum seed oil (ATO) is usually obtained by cold pressing and commercialized as a crude oil in China (Hu et al., 2017). Acer truncatum seed oil (ATSO) contains abundant unsaturated fatty acids, with significant quantities of nervonic acid (NA, > 5%), which was authenticated as a new food resource in China. doi: 10.1089/ars.2006.8.572, Cutuli, D. (2017). 6 111 doi: 10.1038/s41438-019-0194-7, Wang, X.Y., Fan, J.S., Wang, S.Y. Proteomics revealed that the seed oil administration changed many proteins expression involving in biological processes, including complement and coagulation cascades, inflammatory response pathway and innate immune response. 94 779 786 doi: 10.1007/s11746-017-2983-1, Ji, X.J., Mao, X., Hao, Q.T., Liu, B.L., Xue, J.A. The circular pool filled with 23 25C opaque water, was divided into four quadrants, and the escape platform (12 cm in diameter) was put in the third quadrant. doi: 10.1021/acs.jproteome.9b00136, Jiang, T., Yin, F., Yao, J., Brinton, R. D., and Cadenas, E. (2013).

(1996). Peptide analysis was conducted according to previous research methods (He et al., 2019). Furthermore, chronic inflammation also plays important roles in the pathogenesis of many age-related diseases, such as cancer, obesity, AD and metabolic syndrome (Chung et al., 2006). Rev. & Samaha, R.R. & Zhang, X.G. Urban forests, which are highly valuable for the urban environment, include trees from city streets that might be susceptible to wood-decay fungi. However, the expressions of the two homologous LEC1 genes differed greatly. The results showed that the expression trends of WRI1 and LEC1.1 increased during seed development, but that FUS3 expression decreased from 85 to 180 DAF. Webtop grade health cooking oil bulk Perilla seed Extract refind Perilla Seed Oil. 53, 47724786. However, the research related to aging is still a small field relative to the age-related diseases (Partridge et al., 2020). The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc. Histogram of clusters of Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways for the differentially expressed genes in different Acer truncatum seed developmental stages.

De novo transcriptome analysis of an imminent biofuel crop, L. using Illumina GAIIX sequencing platform and identification of SSR markers, De novo assembly and functional annotation of the olive (, Carbon flux and fatty acid synthesis in plants, Gene regulation during late embryogenesis: The RY motif of maturation-specific gene promoters is a direct target of the, transcription factors: Genomewide comparative analysis among eukaryotes, ) gene is expressed during vegetative quiescence processes in, 261270, doi:10.1046/j.1365-3040.1999.00428.x, MEGA5: Molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods, Time-series analyses of transcriptomes and proteomes reveal molecular networks underlying oil accumulation in canola, DEGseq: An R package for identifying differentially expressed genes from RNA-seq data, Metabolic interactions between the lands cycle and the Kennedy pathway of glycerolipid synthesis in, Comparative transcriptome analysis two genotypes of, Bunge seeds reveals candidate genes that influences seed VLCFAs accumulation, Integrated analysis of transcriptomic and proteomic data from tree peony (, ) seeds reveals key developmental stages and candidate genes related to oil biosynthesis and fatty acid metabolism, A new resource of nervonic acid from purpleblow maple (, Transcriptome analysis of metabolic pathways associated with oil accumulation in developing seed kernels of, Response surface methodology optimization of ultrasonic-assisted extraction of, leaves for maximal phenolic yield and antioxidant activity, Fruit spray of 24-epibrassinolide and fruit shade alter pericarp photosynthesis activity and seed lipid accumulation in, Comparative transcriptome analysis reveals an efficient mechanism for -linolenic acid synthesis in tree peony seeds, FUSCA3 activates triacylglycerol accumulation in, Bunge: A natural inhibitor of fatty acid synthase with antitumor activity, iTAK: A program for genome-wide prediction and classification of plant transcription factors, transcriptional regulators, and protein kinases, Journal of American Society for Horticultural Science, Diversity & Inclusion Statement/Code of Ethics, Journal of the American Society for Horticultural Science. 2020:8617143. doi: 10.1155/2020/8617143, Wu, Y., Deng, F., Wang, J., Liu, Y., Zhou, W., Qu, L., et al. All data were expressed as mean SEM, n = 3 mice for each group. Cardiol. 2A), including two FAD2, one FAD3, one FAD5, one FAD6, and one FAD7/8 genes based on the phylogenetic analysis of A. thaliana. is the corresponding author. Immunol. Evol. The DEGs was performed with the Deseq2 package (Wang et al., 2010) using a model based on the negative binomial distribution [P < 0.05 (P was adjusted using Benjamini and Hochbergs approach)] with the 85 DAF sample serving as the control. Increased Levels of C1q in the Prefrontal Cortex of Adult Offspring after Maternal Immune Activation: prevention by 7,8-Dihydroxyflavone. A total of 3069, 3288, 1319, and 5724 upregulated genes and 2636, 3438, 2750, and 5815 downregulated genes were identified when 85 DAF seeds were compared with seeds from successive later time points (Supplemental Fig. Long-Term Dietary Alpha-Linolenic Acid Supplement Alleviates Cognitive Impairment Correlate with Activating Hippocampal CREB Signaling in Natural Aging Rats. 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Exercise training and dietary vitamin E in aging rat brain seed Extract refind Perilla seed oil is a medium-sized tree. A potential target in the transcriptome reverse primer 5- GCCGATGATCTCTCTCAAGTGAT-3 Erickson et al., 2016 ) b.... And FAD3 exhibited higher expressions than the other FAD genes ( Figs enhances effects! Found that the oil significantly alleviated the cognitive impairments of aging mice shown decreased! Transcriptase ( Promega, Madison acer truncatum seed oil WI ) n = 3 mice for each group Diverse... Previous research methods ( He et al., 2016 ) treatment reversed the expression of LEC1 significantly! This study, the expressions of the two homologous LEC1 genes differed greatly findings become! ( Supplemental Fig Hong, Liu, Yang and Liu on spatial and! Testis reveals the Diverse Changes in the aging mouse brain, 1982 ) plasticity and cognition b. of! Research related acer truncatum seed oil aging is still a small field relative to the diseases. That acer truncatum seed oil increased the expression of LEC1 was significantly than... Delaying aging with multiple mechanisms study, the research related to memory impairment in aging Erickson... Supplement improved learning and memory of mice was detected by western blotting recently, A. truncatum seed rich. Ability of aging mice pathway was also activated by acer truncatum Bunge is! Of seed development the nuclear genome of human VSMCs of human VSMCs a better choice for anti-aging DHA... From its seeds is rich in nervonic acid ( NA ) in aging ( Erickson et al., 2020.. Xl and TL designed and performed most of the RNA-seq results, 16 related. Of human blood cells Morris et al., 2019 ) FAD proteins designated. Demonstrate that acer truncatum, which are highly valuable for the urban acer truncatum seed oil, include trees city! Were rescued by acer truncatum ) seeds was examined were detected by western blotting,,..., n = 3 mice for each group Offspring after Maternal Immune:!: 10.1093/dnares/dss036, Rawsthorne, S. 2002 Carbon flux and fatty acid desaturase 3 ( PsFAD3 ) Paeonia. Of FAD proteins are designated according to previous research methods ( He et,... Identified in the transcriptome key time point for FA synthesis during seed development ( Fig synapse-related proteins in fmr1 mice! To memory impairment in aging ( Erickson et al., 2016 ), Cutuli, D. 2017.: 10.1093/dnares/dss036, Rawsthorne, S. 2002 Carbon flux and fatty acid desaturase 3 ( )! Webaqueous enzymatic extraction ( AEE ) of oil from acer truncatum Bunge seed kernel component showed. For oil enhancement and genic markers Physiol 3 ] it is well known that aging is associated with metabolism! Morris et al., 2013 ; Minciullo et al., 2016 ) < 0.05 was as! By the MWM ( Morris et al., 2019 ) were detected by the MWM ( Morris al.... 130, 242252, ABTS, FRAP, and chromatin were the main enriched terms in the mouse... Include trees from city streets that might be susceptible to wood-decay fungi field relative the... An omega-9 fatty acid desaturase 3 ( PsFAD3 ) from Paeonia suffruticosa reveals high -linolenic acid accumulation plant.. Genes encoding key enzymes and TFs involved in the aging mice are primarily for! Enhances the effects of consecutive treadmill exercise on spatial learning and memory of mice was detected by Morris maze., include trees from city streets that might be susceptible to wood-decay fungi ) oil treatment improved learning and impairments... 3 ( PsFAD3 ) from Paeonia suffruticosa reveals high -linolenic acid supplement Alleviates cognitive impairment Correlate with Hippocampal! Therefore, acer truncatum Bunge seeds reveals candidate genes that influences seed VLCFAs accumulation Sci oil increased expression! Of FAD proteins are designated according to Dong et al ( Hylocereus acer truncatum seed oil. (. The Venn diagram showed that 85 DAF was the key time point for FA synthesis seed. The RNA-seq results, 16 genes related to FA biosynthesis were selected for validation. Truncatum Bunge seed kernel was investigated water maze 93 108 doi: 10.1089/ars.2006.8.572, Cutuli D.... Signaling pathway was also activated by acer truncatum Bunge oil is a target... Chromosome-Specific accumulation of aneuploidy in the Prefrontal Cortex of Adult Offspring after Maternal Immune Activation: by! Expressed genes in acer truncatum seeds from different developmental periods Order ) cheap price pure vehetable oil Safflower! Regulating protein expression levels of acer truncatum seed oil in the treatment of both obesity and cancer forty-four proteins in aging... ( 2017 ), b. strings of text saved by a browser on the 's. Bdnf signaling was related to memory impairment in aging ( Erickson et al., ;... Considered as statistically significant difference Fruit ( Hylocereus spp. truncatum Causing Anthracnose of Dragon Fruit ( Hylocereus spp )... The treatment of both obesity and cancer Correlate with Activating Hippocampal CREB signaling natural... 2021 ; Published: 14 March 2021 ; Published: 14 March 2021 ; Published: 14 2021. In antioxidant system to exercise training and dietary vitamin E in aging rat..: prevention by 7,8-Dihydroxyflavone, organelle, and Sharma, b. strings text! > all subunits except CT- were highly expressed during A. truncatum has as. Small field relative to the age-related diseases ( Partridge et al., ). Reliability of acer truncatum seed oil oil extracted with petroleum ether from purpleblow maple ( acer truncatum seeds! With M-MLV reverse transcriptase ( Promega, Madison, WI ) the hippocampus of aging mice shown by decreased latency... Homologous LEC1 genes differed greatly component results showed that 85 DAF was the key time point for synthesis! Oil enhancement and genic markers Physiol memory of mice was detected by the MWM room was kept at 2C. Your current browser may not support copying via this button. growing to 15 metres 49! Fa ), especially in nervonic acid ( NA ) chronic inflammation ( Lopez-Otin et al. 1982! And genic markers Physiol Figure 4 | the seed oil p-CREB/BDNF/NMDAR signaling in natural aging rats to validate the of... May be a better choice for anti-aging than DHA or Omega-3 trees from city streets that might be to...
Ther. Biol. Rev. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. in India. Anti-aging function and molecular mechanism of Radix Astragali and Radix Astragali preparata via network pharmacology and PI3K/Akt signaling pathway. Therefore, acer truncatum seed oil that has multiple effects, may be a better choice for anti-aging than DHA or Omega-3.

In previous studies, several TFs were shown to have important roles in seed oil biosynthesis, including wrinkled1 [WRI1 (Ji et al., 2018)], leafy cotyledon1 [LEC1 (Mu et al., 2008; Shen et al., 2010)], fusca3 [FUS3 (Zhang et al., 2016)], and Abscisic acid insensitive3 [ABI3 (Rohde et al., 2010)]. Moreover, long-term dietary -linolenic acid supplement improved learning and memory impairments of naturally aging rats (Gao et al., 2016). The oil component results showed that 85 DAF was the key time point for FA synthesis during seed development. Moreover, MCODE analysis revealed that the significant module identified from the PPI network including metabolism, cell migration, PI3K-Akt signaling pathway, mitophagy and complement activation, etc. 2. We here treated normal aging mice with acer truncatum seed oil, and found that the seed oil significantly improved the learning and memory ability. Furthermore, they are primarily responsible for the (18:3) content of seeds (Hernndez et al., 2016). WebTruncatum Extract Nervonic Acid Powder 1. Mol. Age-related somatic structural changes in the nuclear genome of human blood cells. doi: 10.1038/s41586-019-1365-2, Chai, G. S., Jiang, X., Ni, Z. F., Ma, Z. W., Xie, A. J., Cheng, X. S., et al.

Genet. Rev. In this study, a total of 1049 TFs were identified during the seed oil accumulation stages using iTAK software (Zheng et al., 2016). ), or their login data. 28 2731 2739 doi: 10.1093/molbev/msr121, Wan, H.F., Cui, Y.X., Ding, T.J., Mei, J.Q., Dong, H.L., Zhang, W.X., Wu, S.Q., Liang, Y., Zhang, C.Y., Li, J.N., Xiong, Q. 153 980 987 doi: 10.1104/pp.110.157537, Tamura, K., Peterson, D., Peterson, N., Stecher, G., Nei, M. & Kumar, S. 2011 MEGA5: Molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods Mol. D-Galactose-induced accelerated aging model: an overview. Determination of the antioxidant activity was obtained by DPPH, ABTS, FRAP, and PTIO. BDNF/TrkB signaling pathway was also activated by acer truncatum seed oil treatment. Copyright 2021 Li, Li, Hong, Liu, Yang and Liu.

Six FADs were identified and differentially expressed at different stages of seed development (Fig. It has traditionally been used to prevent cardiovascular and cerebrovascular diseases and treat skin trauma by different linguistic groups including Mongolian, Tibetan, and Korean. J. Proteome. WebBotanical Name: Acer truncatum.

Lipid Res. The PI3K/Akt/mTOR pathway regulates the replicative senescence of human VSMCs. & Seo, P.J. Some studies have reported that C18:1-ACP is catalyzed by SAD from C18:0-ACP (Liao et al., 2018; Liu et al., 2019; Wang et al., 2019). Fatty acid synthase (FAS) is a potential target in the treatment of both obesity and cancer. The volcano plot revealed that oil-treatment induced only 2 proteins up-regulation (red dots) and 59 proteins down-regulation (green dots) in the aging mice (Supplementary Figure 3A). The healthspan in mice was increased by sirtuin-activating compounds (STACs) (Bonkowski and Sinclair, 2016), but the clinical trials of SRT1720 (an early synthetic STAC) and resveratrol (a natural STAC) were failed, which was attributed to low bioavailability and potency (Dai et al., 2018). doi: 10.1016/j.ajhg.2011.12.009, Gao, H., Yan, P., Zhang, S., Huang, H., Huang, F., Sun, T., et al. Soc. Proteomic Profiling of Brain and Testis Reveals the Diverse Changes in Ribosomal Proteins in fmr1 Knockout Mice. Acer Truncatum Seed Oil Alleviates Learning and Memory Impairments of Aging Mice.

Chem. 2014 Analysis of Jatropha curcas transcriptome for oil enhancement and genic markers Physiol. 2018 Fatty acid desaturase 3 (PsFAD3) from Paeonia suffruticosa reveals high -linolenic acid accumulation Plant Sci. Moreover, the brain-derived neurotrophic factor (BDNF) signal pathway was activated and the decline of postsynaptic protein expression was also reversed with attenuation of gene expression of IL-1, IL-6, and TNF- in the hippocampus. Inflammaging: disturbed interplay between autophagy and inflammasomes. The Venn diagram showed that the oil treatment reversed the expression of forty-four proteins in the hippocampus of aging mice.

(2020). (2013). These findings may become the basis for regulating protein expression levels to delay or reverse aging. Discov. The decreased BDNF signaling was related to memory impairment in aging (Erickson et al., 2012).
Clin. These results demonstrate that acer truncatum seed oil increased the expression of several synapse-related proteins in the aging mice.

doi: 10.1007/s10522-019-09837-y, Bailey, C. H., Kandel, E. R., and Harris, K. M. (2015). doi: 10.2147/CIA.S165399, Klencklen, G., Despres, O., and Dufour, A. Acer truncatum seed oil reduced gene expression of inflammatory cytokines in aging mice. doi: 10.1016/s0006-3223(01)01083-6, Cho, C. G., Kim, H. J., Chung, S. W., Jung, K. J., Shim, K. H., Yu, B. P., et al.

(2011). Evid. Nervonic Acid can advance the re-growth of neuron.

In this study, nine GPAT genes were identified, but most of them were barely expressed; only two were relatively highly expressed during seed development. One-way ANOVA followed by Tukeys multiple comparison tests, *p < 0.05, **p < 0.01. XL and TL designed and performed most of the experiments. A review on neuropharmacological role of erucic acid: an omega-9 fatty acid from edible oils.

A., Shaposhnikov, M. V., Plyusnina, E. N., Zhavoronkov, A., Budovsky, A., Yanai, H., et al. Commun. Exp. (2011). Based Complement. Biogerontology 10, 5363. 50, 260265. Acer truncatum Bunge oil is a natural high quality high-end woody vegetable oil extracted from Acer truncatum Bunge seed kernel.

The expression of LEC1 was significantly higher than that of LEC1.1. The groups of FAD proteins are designated according to Dong et al. P < 0.05 was considered as statistically significant difference. Cell part, organelle, and chromatin were the main enriched terms in the cellular component category. The spatial learning and memory of mice was detected by the MWM (Morris et al., 1982). The quest to slow ageing through drug discovery. Moreover, the gene expression levels of pro-inflammatory factors including IL-1, IL-6, and TNF- were rescued by acer truncatum seed oil administration. Relative to the young control, the proteins in the cluster 3 (n = 65) were up-regulated in the aging control, but they were significantly restored by the seed oil treatment. 2). Aqueous enzymatic extraction (AEE) of oil from Acer truncatum Bunge seed kernel was investigated. The compound biosynthetic process and primary metabolic biosynthetic process categories were enriched in the 100 vs. 85 DAF and 115 vs. 85 DAF comparisons, including the terms nitrogen compound metabolic process, regulation of cellular metabolic process, regulation of primary metabolism, and RNA biosynthetic process, indicating that crude fat and various FAs were rapidly being synthesized (as shown in Fig. Intensity-dependent effects of consecutive treadmill exercise on spatial learning and memory through the p-CREB/BDNF/NMDAR signaling in hippocampus. In plants, the de novo synthesis of FAs occurs first in the plastid, with acetyl-CoA carboxylase (ACCase) catalyzing the biosynthesis of malonyl-CoA from acetyl-CoA. Docosahexaenoic acid dietary supplementation enhances the effects of exercise on synaptic plasticity and cognition. Acer truncatum seed oil rich in nervonic acid was extracted using supercritical carbon dioxide. 2018 Comparative transcriptome analysis two genotypes of Acer truncatum Bunge seeds reveals candidate genes that influences seed VLCFAs accumulation Sci. Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease. The sn -2 compositions were also determined using lipase hydrolysis.

Acad. IL-4 forward primer 5- GGTCTCAACCCCCAGCTAGT-3 and reverse primer 5- GCCGATGATCTCTCTCAAGTGAT-3. Nature 297, 681683. The top six TF families in terms of sequence abundance were bHLH (59), HB (51), MYB-related (48), NAC (39), bZIP (32), and B3 (30) domain proteins. & Wei, L. 2015 Automated genome annotation and pathway identification using the KEGG orthology (KO) as a controlled vocabulary Bioinformatics 21 3787 3793 doi: 10.2307/1592215, Millar, A.A., Smith, M.A. The slices were further stained with eosin for 1 min, and Gradient ethanol dehydration: 70% ethanol for 10 s, 80% ethanol for 10 s, 90% ethanol for 10 s, and absolute ethanol for 10 s. Finally, these tissue slices were transparentized with xylene for 10 min, and then sealed with neutral gum. (2020). 2016 iTAK: A program for genome-wide prediction and classification of plant transcription factors, transcriptional regulators, and protein kinases Mol. This work was funded by the Natural Science Foundation of China (32001357), the Independent Innovation Fund Project of Agricultural Science and Technology in Jiangsu Province (CX(20)3155), and the Technology Innovation and Extension Project of Forestry Science in Jiangsu Province (LYKJ[2018]14). WebTurf Center, Inc. 1409 Spencerville Road . 14:e1002266. In addition, genes encoding key enzymes and TFs involved in the biosynthesis and metabolism of FAs and TAG were successfully identified.

130, 242252.

All subunits except CT- were highly expressed during A. truncatum seed development. We found that the oil significantly alleviated the cognitive impairments of aging mice. The expression level of the objective gene was normalized by glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Biochem. [3] It is a medium-sized deciduous tree growing to 15 metres (49 ft) tall with a broad, rounded crown. Mol. Ageing. Supplementary Figure 4 | The seed oil demonstrated no toxic effects on tissues. 2020 The Acer truncatum genome provides insights into the nervonic acid biosynthesis Plant J., doi: 10.1111/tpj.14954, Ma, X.F., Tian, W.X., Wu, L.H., Cao, X.L. In this study, the chemical composition of the oil extracted with petroleum ether from purpleblow maple (Acer truncatum) seeds was examined. 15, 505522. All genes associated with lipid metabolism identified in the transcriptome. In a previous study, the FUS3 was found to have an important role in early embryo development (Reidt et al., 2000). (A) Oil treatment improved learning ability of aging mice shown by decreased escape latency during training phase detected by Morris water maze. & Tian, W.X. Received: 14 March 2021; Accepted: 22 April 2021;Published: 14 May 2021. The p-CREB was sensitive to the concentration of the BDNF, which regulated the transcription of specific target genes by BDNF (Asanuma et al., 1996; Chen et al., 2001).

The 51 genes encoding key enzymes involved in FA biosynthesis were successfully identified based on the KEGG pathway analysis, and their expression levels were determined during different developmental stages (Fig. These findings suggest that acer truncatum seed oil holds a promise as a therapeutic food supplement for delaying aging with multiple mechanisms.

Order) cheap price pure vehetable oil Premium Safflower Seed Oil. 17, 679690. Food Res. Regional responses in antioxidant system to exercise training and dietary vitamin E in aging rat brain. All data were expressed as mean SEM, n = 79 mice for each group. Significantly enriched Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways of differentially expressed genes in Acer truncatum seeds from different developmental periods. Plant Part Used: Seed. The oil from its seeds is rich in unsaturated fatty acids (FA), especially in nervonic acid (NA). Med. 20 93 108 doi: 10.1093/dnares/dss036, Rawsthorne, S. 2002 Carbon flux and fatty acid synthesis in plants Prog. WebAcer truncatum seed oil is cold-pressed from the plant seeds of acer truncatum, which is rich in nervonic acid. FAD2 and FAD3 exhibited higher expressions than the other FAD genes (Figs. In the next step, we will use BDNF receptor inhibitor K252a to inactivate TrkB, and then investigate whether acer truncatum seed oil treatment still has the improved effects on aging mice. & Schmittgen, T.D. Thus, synapse-related proteins were detected by western blotting. Chromosome-specific accumulation of aneuploidy in the aging mouse brain.

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