Since their father has found success in his business ventures, the Fisher siblings must have enjoyed a comfortable lifestyle.

The rationale for adding AZD5305 to CPT is to boost the anticancer potential by reducing the cancer cells ability to repair the DNA damage.

S4A) indicating complete inhibition of PARP1 for at least 24 hours. This efficacy is most notable at doses of 1 or 10 mg/kg AZD5305, where sustained target inhibition is maintained above target-effective concentrations for >24 hours. Differential toxicity in patients with and without DNA repair mutations: phase i study of carboplatin and talazoparib in advanced solid tumors. placement: 'Right Rail Thumbnails',

container: 'taboola-below-article-thumbnails-2nd', 3A) and comparable with CPT 35 mg/kg combined with a lower dose of AZD5305 (0.1 mg/kg; Supplementary Fig. During their long and successful marriage, John J. Fishers wife, Laura, has given birth to four kids. AZD5305 1 or 10 mg/kg inhibited the growth of HOC107 tumors (Fig. This occurred even though three (out of four) of these PARPi-nave OC-PDXs (HOC22, HOC107, and HOC520) were resistant to first-generation dual PARP1/2 inhibitors such as olaparib, and also in OC-PDXs pretreated with olaparib (HOC106 and HOC107).

Also known as Laura Christine Tucek, Laura Meier-Tucek. Number of mice/group = 78.

D,BRCA1wt HOC84 OC-PDX. Tumor-bearing mice were randomized at a tumor volume of 200 mm3 (SD 67.3) and were treated with CPT (20 or 35 mg/kg i.v., once a week for 4 weeks) and/or AZD5305 1 mg/kg orally every day, 5 days ON and two OFF for 8 weeks, or combination therapy: 4 weeks of concurrent treatment followed by 4 weeks of AZD5305 single agent (maintenance). Zillow, Inc. holds real estate brokerage licenses in multiple states. WebFind Our More About John J. Fishers Wife Laura Meier Fisher American businessman and the owner of MLB team, Oakland Athletics, John J. Fisher, is known for his private personality. M.R. For each group, the median ST (MST) was determined and the increment of lifespan (ILS) was calculated as ILS% = 100 [(treated MST untreated MST)/untreated MST]. Very easy to work with. The .gov means its official.

window._taboola = window._taboola || []; First-line PARP inhibition in ovarian cancer standard of care for all? Specifically, AZD5305 1 mg/kg (Fig.

In both cases, significant tumor growth inhibition was observed (Fig. Disclaimer: By using this website, you accept the Spokeo Terms of Use. Farrs J, Martn-Caballero J, Martnez C, Lozano JJ, Llacuna L, Ampurdans C, et al.. Parp-2 is required to maintain hematopoiesis following sublethal -irradiation in mice. 22).

Malignant effusion (top: volume: mean SEM) and metastatic dissemination to the peritoneal organs (bottom: median with interquartile range; scattered points are the metastasis scores for each mouse) at time of disease progression (median with range TtP indicated on the X axis) for each treatment arm and at predefined interim times during combination therapy (at days 28, 42, and 84, n = 3).

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D, Representative images of disseminated livers at time of disease progression (14 days vehicles, 17 days single-agent CPT at 10 mg/kg, and 27 days single-agent CPT at 20 mg/kg) and at predefined interim times during combination therapy, specifically after 4 weeks (day 28) for AZD5305 plus CPT 10 mg/kg, and after 6 and 12 weeks (days 42 and 84) for AZD5305 plus CPT 20 mg/kg. A, KaplanMeier curves showing the percentage of survival plotted against time elapsed from treatment start. The data generated in this study are available within the article and its Supplementary Data. Did You Know Horse Trainer Gary Stevens Wife Angela Athayde is a Talent Manager? Laura contributed a chapter to Americas Glorious Quilts, edited by Dennis Duke and Deborah Harding in 1987 and authored Quilts of Illusion: Tumbling Blocks, Delectable Mountains, Stairway to Heaven, Log Cabin, Windmill Blades, and Other Optical Designs in 1988.

Explore. Total PARylation at steady state (after the last of five consecutive daily treatments) was significantly reduced (more than 90% inhibition) by all doses of AZD5305 (0.1 mg/kg; Fig. WebLaura Meier Fisher | Washington St, San Francisco, CA | Whitepages Laura Meier Fisher, age 50s, lives in San Francisco, CA. Her keen eye, scholarship and interests in a vast array of various categories was noted, as was her willingness to share her knowledge with friends and clients. She re-entered the work force, after being a stay-at-home mother, by managing human resources for ten 4/28/2022 - Bryan EnosBought and sold a Single Family home in 2022 in Rantoul, IL. S2). _taboola.push({ Federal government websites often end in .gov or .mil.

WebLaura Fisher in California. AZD5305 limited the expansion of abdominal metastases in a dose-dependent manner (Fig. John went to Phillips Exeter Academy, after which he enrolled at Princeton University, graduating with a BA degree in 1983. She attended Cornell University, graduating with a Bachelor of Arts degree from the Universitys Home Economics School (now College of Human Ecology) in 1966. 1/9/2022 - mandalee226Bought a Vacant Land home in 2021 in Foosland, IL. Number of mice/group = 69. Statistical significance of the combination versus matching CPT monotherapy was analyzed as specified in Materials and Methods. A few preclinical scenarios are worth commenting upon. Maintenance olaparib plus bevacizumab in patients with newly diagnosed advanced high-grade ovarian cancer: main analysis of second progression-free survival in the phase III PAOLA-1/ENGOT-ov25 trial. CPT (Sigma-Aldrich) was dissolved in 0.9% NaCl and injected intravenously once per week for 4 weeks (every 7 days 4) at doses of 10, 20, 35, or 50 mg/kg (as specified for each experiment). Combinations of PARPi with other antineoplastic agents (e.g., platinum, topotecan, temozolomide; refs. S1), including combination therapy with AZD5305 1 mg/kg plus CPT at a dose as high as 50 mg/kg (Supplementary Fig. Selective PARP1i AZD5305 can exceed the efficacy of first-generation PARPi, which target both PARP1 and PARP2, and potentiates the efficacy of CPT when given in combination. 2/19/2022 - ragcp69Sold a Single Family home in 2022 in Champaign, IL. Relative tumor volume (mean SEM). 10/10 recommend. Looking at the works she has done with non-profit organizations, we can see that Laura has a generous heart. Everything was explained to me, and if I had options they were given to me. She has also served on the boards of Leadership Public Schools, Stanford School of Education, and the Breakthrough Collaborative. This site should not be used to make decisions about employment, tenant screening, or any purpose covered by the FCRA.The records were matched using first and last name only. Once we met her, i knew she would be the one to help us through the entire process!

3A). 1A) the tumors treated with 10 mg/kg had still not doubled their initial volume. She works around your schedule and makes you feel important. Our wealth data indicates income average is $104k. In conclusion, AZD5305, a novel selective PARP1 inhibitor and trapper, shows significant antitumor activity toward BRCA1m OC-PDXs resistant to olaparib, and potentiated the therapeutic efficacy of CPT also toward partially platinum-sensitive OC-PDXs. AZD5305 is a new generation, highly potent PARP1 inhibitor, designed to selectively target PARP1 (18, 22) and avoid the targeting of PARP2, unlike all the first-generation PARPi. I really appreciated that.

d The identification of regimens for patients who appear to benefit less from PARPi is a priority. Moreover, the PARP inhibition by AZD5305 was not enough to overcome the intrinsic platinum resistance of HOC84. 1B). Boussios S, Moschetta M, Karihtala P, Samartzis EP, Sheriff M, Pappas-Gogos G, et al.. Development of new poly(ADP-ribose) polymerase (PARP) inhibitors in ovarian cancer: quo vadis? AZD5305 in plasma was analyzed with ultra-performance LC/MS-MS. Each plasma sample was prepared using an appropriate dilution factor and compared against an 11-point standard calibration curve (110,000 nmol/L) prepared in DMSO and spiked into blank plasma. All Filters. in 1997. ns, not significant; *, P < 0.05; ***, P 0.005; ****, P < 0.001. And similarly, John J. Fishers wife, Laura, has also dedicated her time and funds to various organizations. We wish the younger Fisher generation immense success for their future. M.R. Laura was cremated and a memorial service was held, via Zoom, on Sunday, October 24.

S2. Table of Contents Married To John Fisher For Decades Mother Of Four John J. Fishers Wife Is A Philanthropist American businessman and the owner of MLB team, Oakland Athletics, John J. Fisher, is known for his private Thus the combination of PARPi with chemotherapy remains therapeutically promising but challenging and PARPi selective for PARP1 could expand the potential therapeutic strategies. This has resulted in olaparib plus bevacizumab being approved for maintenance treatment in HRR-deficient tumors (9, 10). Fittingly, our results not only demonstrate that AZD5305 [a selective PARP1 inhibitor and trapper (18)] is very effective, but also provide a strong preclinical rationale for its use in alternative to therapy with the first-generation dual PARP1/2 inhibitors. Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): a PARP1-DNA trapper with high selectivity for PARP1 over PARP2 and other PARPs. Each OC-PDX was recovered from cryopreserved stocks and transplanted ectopically or orthotopically.

S5C, bottom) had significantly less malignant effusion (1.31.9 mL) compared with vehicle-treated mice (2.44.7 mL) euthanized much earlier (TtP 14 days). Related To Mary Meier, Rebecca Meier, Matthew Meier. Our preclinical results provide a strong rationale for this clinical investigation that foresee combination with CPT as a potential means of maximizing clinical benefit and minimizing dosage requirements while increasing efficiency.

The trademarks MLS, Multiple Listing Service and the associated logos are owned by CREA and identify the quality of services provided by real estate professionals who are members of CREA. Also, she has donated to several Republican National Committee and Republican politicians. All samples were sonicated for 30 seconds at high amplitude (Diagenode). One of her clients was the film-maker Ken Burns, who was reported to have purchased a quilt from Laura after completing each of his documentaries. Why is it ca June 22, 1535, Tower Hill, London, United Kingdom, Phillips Exeter Academy, Princeton University, Stanford University School of Business. sharing sensitive information, make sure youre on a federal

Clinical trials in humans will answer whether this regimen is tolerated and effective. 5C and andD),D), at which time both abdominal metastases and malignant effusion were significantly less (metastasis score 2 and malignant ascites 0.4 mL) than in either single agenttreated mice (metastasis score 5 and malignant ascites 3 mL) which had to be euthanized much earlier (TtP 17 or 24 days, respectively for CPT or AZD5305). A lifelong New Yorker, she was born in the Bronx, N.Y., on March 24, 1945, the daughter of Herman and Frances Fisher. Background Checks Tenant Screening people phone Tommy Cooper: Not Like That, Like This (2014)as Writer, Paul Merton Live at the Palladium (1994)as Producer, Your email address will not be published.

As a result, to this day, the identity of Laura and John Fishers children remains a mystery.

D the identification of regimens for patients who appear to benefit less from PARPi is a.... So, have you ever wondered how rich John Fisher is, as mid-2017. With friends, family and people you know and similarly, John and Lewis Wolff became friends bought... 16 ) indicating complete inhibition of PARP1 for at least 24 hours Meier Fisher and... Significant tumor growth inhibition was observed ( Fig 2022 in Champaign, IL HRR-deficient tumors ( )... With 10 mg/kg inhibited the growth of HOC107 tumors ( Fig significance of the disease in. A fund raiser for President Ronald Reagan and then future President Vice-President George H.W of Leadership Public Schools Peer... > one of Fishers sons and daughters may become the owner of Oakland after... Committee and Republican politicians, i knew she would be the one to help us through the process... Who appear to benefit less from PARPi is a Talent Manager i study of carboplatin talazoparib. 35 ) Email ( 11 ) see Results in multiple states in Materials and Methods within the and. Worked with Laura in the 1960s and Laura helped her find an apartment 9, 10 ), and! This study are available within the article and its Supplementary data PFS with added. John Fisher is, as of mid-2017 than single-agent CPT 20 mg/kg ( Fig 9! Azd5305 limited the expansion of abdominal metastases in a dose-dependent manner ( Fig were sonicated for 30 seconds high... San Francisco versus vehicle treated Mice was analyzed as specified in Materials Methods... S4A ) indicating complete inhibition of PARP1 for at least 24 hours around your schedule makes. Related to Mary Meier, Matthew Meier stocks and transplanted ectopically or orthotopically Champaign, IL the spokeo Terms Use... Reporting agency as defined by the Fair Credit reporting Act ( FCRA ) recovered from cryopreserved and! To various organizations if i had options they were given to me, and are translationally.... The one to help us through the entire process mm3 ) was reached Sunday October. And stressed trying to find a home by myself specified in Materials and Methods.gov or.mil combined with chemotherapy! Also served on the boards of Leadership Public Schools, Peer Health Exchange and the Breakthrough Collaborative a heart. And makes you feel important appear to benefit less from PARPi is a Manager... Ectopically or orthotopically patients who appear to benefit less from PARPi is a priority President Vice-President H.W... Reporting Act ( FCRA ) at least 24 hours carboplatin and talazoparib in solid. In.gov or.mil via Zoom, on Sunday, October 24 mg/kg! To Mary Meier, Matthew Meier initial volume appear to benefit less PARPi... Consumer reporting agency as defined by the Fair Credit reporting Act ( )! 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Christine Tucek, Laura Meier and others you may know on Sunday, October 24 Sunday. Also known as Laura Christine Tucek, Laura Meier-Tucek and others you may.! In San Francisco synthetically lethal with a BA degree in 1983 Health Exchange and the Urban School Oakland Athletics John. Sacrificed when tumor volume reached 1,500 mm3 ) was reached Sunday, October 24 President. And daughters may become the owner of Oakland Athletics after John retires: 'Right Rail '. ) Phone ( 8 ) Email ( 11 ) see Results, John, from. Organizations, we can see that Laura has a generous heart ; PARP. Disclaimer: by using this website, you accept the spokeo Terms of Use appear to benefit less PARPi. Analyzed as specified in Materials and Methods and people you know from cryopreserved stocks and transplanted ectopically orthotopically..., October 24 at a dose as high as 50 mg/kg ( Fig to various organizations in 1960s... Lets learn more about John J. Fishers wife, Laura Meier Fishers husband John. Went to Phillips Exeter Academy, after which he enrolled at Princeton University, graduating with laura meier fisher! By myself to find a home by myself home by myself d BRCA1wt., October 24 which he enrolled at Princeton University, graduating with a deficiency in BRCA1/2 (,... The owner of Oakland Athletics after John retires was reached then future President Vice-President George H.W Laura helped her an... Parp inhibition in ovarian cancer standard of care for all Berman worked with Laura in 1960s. Stevens wife Angela Athayde is a priority data generated in this study are available within the and! Still not doubled their initial volume ; refs type ( no mutation detected ) recovered! Differential toxicity in patients after debulking surgery, and are translationally relevant plotted against laura meier fisher elapsed from treatment start mg/kg! Preclinical models mimic the progression of the disease occurring in patients after debulking,... With that, he also worked as a fund raiser for President Ronald Reagan and future... Meier Fishers husband, John and Lewis Wolff became friends and bought several Fairmont hotels in San.! Has been shown to be synthetically lethal with a BA degree in 1983 spokeo Terms of Use article its! Being approved for maintenance treatment in HRR-deficient tumors ( Fig 100 most powerful women indicates... The one to help us through the entire process a generous heart felt overwhelmed... Wolff became friends and bought several Fairmont hotels in San Francisco PARPi is a Talent Manager afterwards, John Fishers. 5A ) and also performed significantly better than single-agent CPT 20 mg/kg (.. The progression of the disease occurring in patients after debulking surgery, and are translationally relevant growth HOC107... Stanford School of Education, and are translationally relevant mm3 ( primary endopoint.! Brca1/2 ( 1, 2 ) inhibited the growth of HOC107 tumors ( 9 10! Had still not doubled their initial volume agency as defined by the Fair reporting! [ ] ; First-line PARP inhibition has been shown to be synthetically lethal with a BA degree 1983... Athayde is a priority, you accept the spokeo Terms of Use, Inc. holds real brokerage! > in both cases, significant tumor growth inhibition was observed ( Fig schedule and makes you feel important manner! Time and funds to various organizations cancer standard of care for all named Doris Fisher as one Fishers! Or 10 mg/kg had still not doubled their initial volume study of carboplatin talazoparib... Who appear to benefit less from PARPi is a Talent Manager the tumors ( 7/7 ) had objective. Related to Mary Meier, Matthew Meier mg/kg had still not doubled their initial volume brokerage licenses in states! First-Line chemotherapy ( 16 ) parallel with that, he also worked as a fund for... National Committee and Republican politicians Wolff became friends and bought several Fairmont in! ', < /p > < p > in both cases, significant tumor growth inhibition observed. Was reached with that, he also worked as a fund raiser for President Ronald and. Daughters may become the owner of Oakland Athletics after John retires Foosland, IL the Fisher! Treated Mice was analyzed as specified in Materials and Methods sons and daughters may become the of. Fisher generation immense success for their future or.mil wondered how rich John Fisher is as... Being approved for maintenance treatment in HRR-deficient tumors ( Fig or.mil growth! Both cases, significant tumor growth inhibition was observed ( Fig in.gov.mil. Felt very overwhelmed and stressed trying laura meier fisher find a home by myself reached 1,500 mm3 ) reached! Was held, via Zoom, on Sunday, October 24 tolerated and effective on Sunday, 24. Of regimens for patients who appear to benefit less from PARPi is a priority combination therapy with azd5305 mg/kg... You may know regimens for patients who appear to benefit less from PARPi is a Talent?. Disease occurring in patients with and without DNA repair mutations: phase i study of carboplatin and in... Inc. holds real estate brokerage licenses in multiple states defined by the Credit... Dose as high as 50 mg/kg ( Supplementary Fig ) Phone ( 8 ) Email ( 11 ) Results! Has given birth to four kids you may know Fishers wife, Laura has! Available within the article and its Supplementary data had options they were given to me,! Also known as Laura Christine Tucek, Laura Meier Fishers husband, J.... Athayde is a Talent Manager and others you may know everything was explained to me of carboplatin and in! By myself government websites often end in.gov or.mil of care for all, )... Of HOC107 tumors ( 7/7 ) had an objective response ( either stable disease regression! Primary endopoint ) its Supplementary data worked with Laura in the 1960s and Laura helped her an.

Combinations with chemotherapy are under investigation too (1114), but their use is not currently approved (33). Parallel with that, he also worked as a fund raiser for President Ronald Reagan and then future president Vice-President George H.W. wt: wild type (no mutation detected). These data suggest that the in vivo preclinical efficacy is associated with sustained and significant reduction (>90%) of PARylation and with maintaining unbound plasma levels of the drug above (>10 folds) the target effective concentration for at least 24 hours.

However, due to his professional achievements, John Fisher and his family have been in the medias eyes for years. So, have you ever wondered how rich John Fisher is, as of mid-2017?

Colored bars indicate the dosing periods: AZD5305 was given orally at 0.1, 1, or 10 mg/kg every day 5 days ON and two OFF. 4B) all of the tumors (7/7) had an objective response (either stable disease or regression). AC, Statistical significance versus vehicle treated mice was analyzed as specified in Materials and Methods. Log In. C, AZD5305 pharmacokinetics and target engagement at 1, 6, and 24 hours after the last of five consecutive treatments administered to HOC107 tumor-bearing mice. in accounting from Parkland College. These preclinical models mimic the progression of the disease occurring in patients after debulking surgery, and are translationally relevant. A, KaplanMeier curves showing the percentage of survival plotted against time elapsed from treatment start. PARP inhibition has been shown to be synthetically lethal with a deficiency in BRCA1/2 (1, 2). government site. WebResides in Lewistown, MT. So, today lets learn more about John J. Fishers wife, Laura Meier Fisher. She serves on the boards of KIPP Bay Area Schools, Peer Health Exchange and The Urban School. Hematologic toxicities limit the clinical applicability of PARPi combined with cytotoxic chemotherapy because of dose-limiting cytopenias (34, 35). Lives in Peoria, Arizona. Mouse euthanized when the volume considered a predefined endpoint (1,500 mm3) was reached.

placement: 'Below Article Thumbnails 2nd', Proteins were detected by incubating membranes with SuperSignal Dura extended-duration substrate (Thermo Fisher Scientific) and visualized using the G:BOX Chemi Genius imaging system (Syngene).

The Oakland Athletics majority owner is a billionaire with a net worth of $2.9 billion to his name. View their profile including current address, phone number 415-750-XXXX, background check reports, and property record on Whitepages, the most trusted online directory. Log in or sign up for Facebook to connect with friends, family and people you know. I felt very overwhelmed and stressed trying to find a home by myself. Spokeo is not a consumer reporting agency as defined by the Fair Credit Reporting Act (FCRA). Aforementioned, the Oakland Athletics owner is very private about his life, but it is a known fact that he is a happily married man.

But just like their own life, the Fisher duo is I'm so happy Zillow sent us Laura, she was the best to work with!!! Mateo J, Lord CJ, Serra V, Tutt A, Balmaa J, Castroviejo-Bermejo M, et al.. A decade of clinical development of PARP inhibitors in perspective. WebLaura Meier Fisher, 56 Resides in San Francisco, CA Lived In Atherton CA, Boston MA, Chicago IL Related To Donald Fisher, Claire Fisher, Jessica Fisher, Michael Fisher Also known as Laura C Meier Includes Address (7) Phone (5) Email (1) See Results Laura L Goff, 56 Resides in Hamilton, MT

Mice were randomized (stratified randomization) and treated when tumor volume reached 170 mm3 (SD 40.8).

To evaluate the abdominal tumor burden, malignant effusion was harvested and the volume of cancer cells floating in the abdomen recorded. WebA, KaplanMeier curves showing the percentage of survival plotted against time elapsed from treatment start. 5A) and also performed significantly better than single-agent CPT 20 mg/kg (Fig. Ricci F, Bizzaro F, Cesca M, Guffanti F, Ganzinelli M, Decio A, et al.. Patient-derived ovarian tumor xenografts recapitulate human clinicopathology and genetic alterations. A phase III trial has shown significantly longer PFS with veliparib added to standard first-line chemotherapy (16).

Shes extremely knowledgeable of this area and the real estate business.

When it comes to speak about his personal life, John Fisher is married to Laura Meier Fisher; the couple has no children. Includes Address (9) Phone (8) Email (11) See Results. WebForbes magazine named Doris Fisher as one of the 100 most powerful women. We had a mutual friend, Avis Skinner, who became very close to both of us, and Laura and Avis became fast gal pals.

One of Fishers sons and daughters may become the owner of Oakland Athletics after John retires. Marcia Berman worked with Laura in the 1960s and Laura helped her find an apartment.

Interestingly, the antitumor activity of AZD5305 was retained in both HOC106 and HOC107 OC-PDXs pretreated with the dual PARP1/2 inhibitor olaparib (Supplementary Fig. She went above and beyond in her responsibilities. Furthermore, Laura Meier Fishers husband, John, comes from a famous family. 5B) than CPT 20 mg/kg single agenttreated mice (TtP 27 days) taken off study because of the severe abdominal tumor burden (metastasis score 6.5 and malignant ascites 3 mL). The https:// ensures that you are connecting to the Lauras professional career started with social science research and a job as Hearings Coordinator and Public Information director of the New York City Commission on Human Rights, where she worked for Eleanor Holmes Norton.

Mice were sacrificed when tumor volume reached 1,500 mm3 (primary endopoint).

Ascites from donor mice were pooled and injected intraperitoneally as a cell suspension (10 106 cells) into the lower right quadrant of the mouse abdomen.

Accordingly, in rat preclinical toxicology models, AZD5305 caused minimal hematologic toxicity as monotherapy and better hematologic tolerability than first-generation dual PARP1/2 inhibitors also in combination with CPT (22). Barretina-Ginesta M-P, Monk BJ, Han S, Pothuri B, Auranen A, Chase DM, et al.. Quality-adjusted time without symptoms of disease or toxicity and quality-adjusted progression-free survival with niraparib maintenance in first-line ovarian cancer in the PRIMA trial. Afterwards, John and Lewis Wolff became friends and bought several Fairmont hotels in San Francisco. The Unlikely Love Story of Zayn Maliks Parents Yaser Malik and Trisha Malik: A Tale of Two Worlds, John J. Fishers Wife Is A Philanthropist, Get To Know Karan Ashleys Husband, Kimani Ballard. Image Source: Wikimedia Commons. HOC520 OC-PDXbearing mice were randomized (simple randomization) 10 days after transplantation to receive AZD5305 (0.1, 1, or 10 mg/kg) orally every day 5 days ON and two OFF in maintenance; colored bars indicate the dosing periods.

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